物理学院“博约学术论坛”系列报告第 140 期

题目：Potein Thin Film Memory for Mobile Devices
报告人：Prof. V. Renugopalakrishnan（Northeastern University and Harvard Medical School）
时 间：2018年1月25日（星期四）上午10点
地 点：中教楼610会议室
报告摘要：
Abstract:  Bacteriorhodopsin (bR) from halobacteria has assumed an important role in technological applications. It is an integral trans-membrane protein, originally discovered and isolated from Halobium Halobacterium, by Dietrich Osterhelt in Walther Stoeckenius laboratory at the University of California, San Francisco and subsequently cloned, a library of mutants were developed (FEBS J. 2014 and references therein) for biophotovoltaic (Renu-Seearm Cell), as logic gate for high performance memory devices, singalling. It is a light driven proton pump which assumes a manifold of states on photon impingement.  Soon after its discovery, the first proposals for technical applications of this protein were brought up by Soviet Scientists as a technology demonstator during Preident Leonid Brezhnev’s comprehensive Soviet Science policy. Various technical and in particular optical applications of bR have been explored since that time in several research groups Storage media based on biomolecules may provide a commercially viable alternative to current magnetic and optical storage systems. Our research is aimed at developing the storage media systems based on newly designed thermostable bacteriorhodopsin (bR) mutants and exploring limits of high-density optical recording using far-field and near-field (SNOM) approach. The concept of optical protein-based memory has been of interest since the early 1970s. Yet, no commercially available protein-based memory devices exist. In addition, the discussion includes details on the  potential of using the unparalleled properties of photochromic proteins by  creating an optical data storage disk drive with unmatched features and,  particularly, record-high data densities and rates. Today, a number of laboratories throughout the world are able coat disk substrates with protein films  of various properties. However, it is often perceived that one of the main remaining challenges to be overcome before this technology can be commercialized is the development of thin overcoats. These overcoats are necessary to protect the protein films in the disk drive environment and to ensure an adequate lifetime of the memory device. Protein-based disk recording is one of the most promising technologies for the future of the multi-billion-dollar data storage industry. Manifold of excited states of bR each with its own distinct life time has recently suggested that a bio quantum computer with > TB memory can be designed at least in principle.

简历：
Prof. V. Renugopalakrishnan, American Biophysicist, “Renu” and his group at the Children’s Hospital / Harvard Medical School and Northeastern University focuses on the interface between protein engineering and nanotechnology. He has been on Harvard faculty since 1984, starting from Assistant Professor to a Professor. In recent years his laboratory has been targeting proteins as intelligent and innovative biomaterials in solar cells, fuel cells, very high density data storage, and tagged on to CNT/Graphene for directed drug delivery, sensors. He teaches and is guiding MD PhD program at Walter Bradford Cannon Society, First Year MD Students, “New Pathway in Medical Education” as a part of Harvard-MIT Health Sciences program and is currently spearheading a campus-wide effort in bio inspired devices. He is funded by NSF, US Air Force, NIH. He was Wallace H Coulter Chair and Professor at the University of Florida, Miami. He had been a visiting Professor in Denmark, Taiwan, India. He obtained his B.Sc. from the Madras University, entered graduate school in the Dept. of Chemistry, Columbia University, New York, NY and Rockefeller University, New York, NY working with Prof Harold C Urey, Nobel Chemistry Laureate and Prof. Barbara Low and obtained his Ph.D. in Biophysical Sciences from State University of New York, Buffalo, New York. He is the author of more than 250 publications, 2 monographs – 1991, 2006, 1 Graduate Level Textbook in Bionanoscience (under development), and member of academies. He was the Editor in-Chief, Journal of Bionanoscience, Associate Editor, Journal of Nanoscience and Nanotechnology and serves on 6 Editorial Boards of Journals. His scientific lineage or ancestry traces its origin to Prof G N Ramachandran, FRS, Biochemistry to Nobel Laureate Prof. Stanford Moore, Rockefeller University, New York, NY; experimental studies of protein structural biology to Prof Dan Wesley Urry, Univ. of Minnesota, Minneapolis; Prof Melvin J Glimcher, Harvard to mineralization of connective tissue macromolecules, to Prof. Richard Collins Lord, MIT on Raman Spectroscopy of Proteins. He along with Dr. Sowmya Viswanathan is organizing one of the largest programs focused on Bio inspired Systems and Devices

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